IL18R1

The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene.cite web | title = Entrez Gene: IL18R1 interleukin 18 receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8809| accessdate = ] IL18R1 is also known as CDw218a (cluster of differentiation w218a).

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.cite web | title = Entrez Gene: IL18R1 interleukin 18 receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8809| accessdate = ]

ee also

* Interleukin-18 receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sergi B, Penttila I |title=Interleukin 18 receptor. |journal=J. Biol. Regul. Homeost. Agents |volume=18 |issue= 1 |pages= 55–61 |year= 2005 |pmid= 15323361 |doi=
*cite journal | author=Parnet P, Garka KE, Bonnert TP, "et al." |title=IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 3967–70 |year= 1996 |pmid= 8626725 |doi=
*cite journal | author=Lovenberg TW, Crowe PD, Liu C, "et al." |title=Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2). |journal=J. Neuroimmunol. |volume=70 |issue= 2 |pages= 113–22 |year= 1996 |pmid= 8898719 |doi=
*cite journal | author=Torigoe K, Ushio S, Okura T, "et al." |title=Purification and characterization of the human interleukin-18 receptor. |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 25737–42 |year= 1997 |pmid= 9325300 |doi=
*cite journal | author=Dale M, Nicklin MJ |title=Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. |journal=Genomics |volume=57 |issue= 1 |pages= 177–9 |year= 1999 |pmid= 10191101 |doi= 10.1006/geno.1999.5767
*cite journal | author=Hoshino K, Tsutsui H, Kawai T, "et al." |title=Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. |journal=J. Immunol. |volume=162 |issue= 9 |pages= 5041–4 |year= 1999 |pmid= 10227969 |doi=
*cite journal | author=Sareneva T, Julkunen I, Matikainen S |title=IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells. |journal=J. Immunol. |volume=165 |issue= 4 |pages= 1933–8 |year= 2000 |pmid= 10925275 |doi=
*cite journal | author=Kumar S, Hanning CR, Brigham-Burke MR, "et al." |title=Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production. |journal=Cytokine |volume=18 |issue= 2 |pages= 61–71 |year= 2003 |pmid= 12096920 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gutzmer R, Langer K, Mommert S, "et al." |title=Human dendritic cells express the IL-18R and are chemoattracted to IL-18. |journal=J. Immunol. |volume=171 |issue= 12 |pages= 6363–71 |year= 2004 |pmid= 14662834 |doi=
*cite journal | author=Azam T, Novick D, Bufler P, "et al." |title=Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex. |journal=J. Immunol. |volume=171 |issue= 12 |pages= 6574–80 |year= 2004 |pmid= 14662859 |doi=
*cite journal | author=Towne JE, Garka KE, Renshaw BR, "et al." |title=Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. |journal=J. Biol. Chem. |volume=279 |issue= 14 |pages= 13677–88 |year= 2004 |pmid= 14734551 |doi= 10.1074/jbc.M400117200
*cite journal | author=Cardoso SP, Keen L, Bidwell J |title=Identification of two novel single nucleotide polymorphisms in the promoter of the human interleukin-18 receptor alpha. |journal=Eur. J. Immunogenet. |volume=31 |issue= 1 |pages= 27–9 |year= 2004 |pmid= 15009178 |doi=
*cite journal | author=Reddy SA, Lin YF, Huang HJ, "et al." |title=The IL-1 receptor accessory protein is essential for PI 3-kinase recruitment and activation. |journal=Biochem. Biophys. Res. Commun. |volume=316 |issue= 4 |pages= 1022–8 |year= 2004 |pmid= 15044087 |doi= 10.1016/j.bbrc.2004.02.155
*cite journal | author=Yoon- DY, Cho YS, Park JW, "et al." |title=Up-regulation of reactive oxygen species (ROS) and resistance to Fas-mediated apoptosis in the C33A cervical cancer cell line transfected with IL-18 receptor. |journal=Clin. Chem. Lab. Med. |volume=42 |issue= 5 |pages= 499–506 |year= 2005 |pmid= 15202785 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Fukushima K, Ikehara Y, Yamashita K |title=Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production. |journal=J. Biol. Chem. |volume=280 |issue= 18 |pages= 18056–62 |year= 2005 |pmid= 15760905 |doi= 10.1074/jbc.M413297200
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466
*cite journal | author=Sahar S, Dwarakanath RS, Reddy MA, "et al." |title=Angiotensin II enhances interleukin-18 mediated inflammatory gene expression in vascular smooth muscle cells: a novel cross-talk in the pathogenesis of atherosclerosis. |journal=Circ. Res. |volume=96 |issue= 10 |pages= 1064–71 |year= 2005 |pmid= 15860756 |doi= 10.1161/01.RES.0000168210.10358.f4

External links

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