Cancer procoagulant

Cancer procoagulant

Cancer procoagulant is a hypothesised protein, most likely a cysteine protease enzyme (EC number|3.4.22.26), that occurs only in fetal and malignant cells. Its activity appears to be the activation of factor X, one of the coagulation factors, and would account for the increased incidence of thrombosis in cancer patients. Tissue factor (TF) is also known to be present at increased levels around malignant cells.

References

* De Cicco M. "The prothrombotic state in cancer: pathogenic mechanisms." Crit Rev Oncol Hematol 2004;50:187-96. PMID 15182825.

External links

*


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • Coagulation — This article is about blood clotting. For other meanings see Coagulation (disambiguation). Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis, the cessation of blood loss from a damaged vessel,… …   Wikipedia

  • Cysteine protease — Cysteine Peptidase Crystal structure of the cysteine peptidase papain in complex with its covalent inhibtor E 64. Rendered from PDB 1PE6 Identifiers …   Wikipedia

  • List of EC numbers (EC 3) — This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 3.1: Acting on Ester BondsEC… …   Wikipedia

  • Cathepsin C — PDB rendering based on 1k3b …   Wikipedia

  • Caspase-9 — Caspase 9, apoptosis related cysteine peptidase PDB rendering based on 1jxq …   Wikipedia

  • Hydrolase — Cristal de lysozyme Les hydrolases constituent une classe d enzymes qui catalysent les réactions d hydrolyse de molécules suivant la réaction générale : R R + H2O ⇌ R OH + R H On y trouve par exemple les estérases, qui hydrolysent les …   Wikipédia en Français

  • Cruzipain — is a cysteine protease expressed by Trypanosoma cruzi.[1] It is classified under EC 3.4.22.51. References ^ Lalmanach G, Boulangé A, Serveau C, et al. (May 2002). Con …   Wikipedia

  • EC 3.4 — Le groupe EC3.4 est un groupe d enzymes appartenant à la famille des hydrolases. Leur rôle est de découper un polypeptide, d où leur nom générique de peptidases. La réaction chimique qu elles catalysent est : AA1 CO NH AA2 + H2O ⇌ AA1 COOH + …   Wikipédia en Français

  • Pulmonary embolism — Classification and external resources Chest spiral CT scan with radiocontrast agent showing multiple filling defects both at the bifurcation and in the pulmonary arteries. ICD 10 …   Wikipedia

  • Thrombophilia — Classification and external resources …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”