JWH-015

Drugbox
IUPAC_name = (2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone

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CAS_number = 155471-08-2
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PubChem = 4273754
DrugBank =
C=23|H=21|N=1|O=1
molecular_weight = 327.43 g/mol
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legal_status = Legal
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JWH-015 is a drug from the aminoalkylindole family, which acts as a subtype-selective cannabinoid agonist. Its affinity for CB₂ receptors is 13.8nM, while its affinity for CB₁ is 383nM, meaning that it binds almost 28x more strongly to CB₂ than CB₁. [Aung MM, Griffin G, Huffman JW, Wu MJ, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB₁ and CB₂ receptor binding. "Drug and Alcohol Dependance" 2000; 60:133-140.] However it still displays some weak CB₁ activity, and is not as selective as newer drugs such as JWH-133. [Marriott KS, Huffman JW. Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor. "Current Topics in Medicinal Chemistry". 2008;8(3):187-204. PMID 18289088]

References