Afimoxifene

Afimoxifene

Chembox new
ImageFile= Afimoxifene.pngImageSize=
IUPACName=("Z")-4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol
OtherNames=4-hydroxytamoxifen
Section1= Chembox Identifiers
CASNo=68392-35-8
PubChem=449459
SMILES=CCC(c1ccccc1)=C(c2ccc(OCCN(C)C)cc2)/c3ccc(O)cc3

Section2= Chembox Properties
Formula=C26H29NO2
MolarMass=387.51396
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=

Section3= Chembox Hazards
MainHazards=
FlashPt=
Autoignition=

Afimoxifenecite web | url = http://www.ama-assn.org/ama1/pub/upload/mm/365/afimoxifene.pdf | title = Statement on a nonproprietary name adopted by the USAN council: Afimoxifene | accessdate = 2008-03-26 | author = | authorlink = | coauthors = | date = | format = | work = | publisher = American Medical Association | pages = | language = | archiveurl = | archivedate = | quote = ] is a selective estrogen receptor modulator whose active ingredient is 4-hydroxytamoxifen which is identical to the active metabolite of tamoxifen.cite journal |author=Desta Z, Ward BA, Soukhova NV, Flockhart DA|title=Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6|journal= J Pharmacol Exp Ther |volume= 310 |issue= 3 |pages= 1062–75 |year= 2004 | doi = 10.1124/jpet.104.065607 |pmid= 15159443] Afimoxifene is a transdermal gel formulation and is being developed by Ascend Therapeutics, Inc. under the trademark TamoGel. Afimoxifene has completed a phase II clinical trial for the treatment of cyclical mastalgia.cite journal | author = Mansel R, Goyal A, Nestour EL, Masini-Etévé V, O'Connell K | title = A phase II trial of Afimoxifene (4-hydroxytamoxifen gel) for cyclical mastalgia in premenopausal women | journal = Breast Cancer Res. Treat. | volume = 106 | issue = 3 | pages = 389–97 | year = 2007 | pmid = 17351746 | doi = 10.1007/s10549-007-9507-x | issn = ]

References

External links

*MeshName|4-hydroxytamoxifen


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Tamoxifen — Systematic (IUPAC) name (Z …   Wikipedia

  • Estrogen — Estriol. Note two hydroxyl ( OH) groups attached to the D ring (rightmost ring) …   Wikipedia

  • Progesterone — Systematic (IUPAC) name Pregn 4 ene 3,20 dione …   Wikipedia

  • Mifepristone — Systematic (IUPAC) name 11β [p (Dimethylamino)phenyl] 17β hyd …   Wikipedia

  • Estradiol — Not to be confused with 17α estradiol. Estradiol Systematic (IUPAC) name …   Wikipedia

  • Progestin — Co inventor Luis E. Miramontes s signed laboratory notebook. October 15, 1951 A progestin is a synthetic[1] progestogen that has progestinic effects similar to progesterone. [2] …   Wikipedia

  • Diethylstilbestrol — Systematic (IUPAC) name 4,4 (3E) hex 3 ene 3,4 diyldiphenol Clinical data AHFS/Drugs.com …   Wikipedia

  • Estrone — Systematic (IUPAC) name 3 hydroxy 13 methyl 6,7,8,9,11,12,13,14,15,16 decahydrocyclopenta[a]p …   Wikipedia

  • Estriol — Identifiers CAS number …   Wikipedia

  • Levonorgestrel — Systematic (IUPAC) name 13 ethyl 17 ethynyl 17 hydroxy 1 …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”