Taranabant

Taranabant

Drugbox
IUPAC_name = N- [(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl] -2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide



CAS_number = 701977-09-5
ATC_prefix = A08
ATC_suffix = AX
PubChem =
DrugBank =
chemical_formula = |C=27|H=25|Cl=1|F=3|N=3|O=2
molecular_weight = 515.95
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
excretion =
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status =
routes_of_administration = Oral

Taranabant (codenamed MK-0364) is a cannabinoid receptor type 1 inverse agonist being investigated as a potential treatment for obesity due to its anorectic effects. [Armstrong HE, Galka A, Lin LS, Lanza TJ Jr, Jewell JP, Shah SK, et al. "Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists." "Bioorganic & Medicinal Chemistry Letters". 2007 Apr 15;17(8):2184-7. PMID 17293109. doi|10.1016/j.bmcl.2007.01.087] [Fong TM, Guan XM, Marsh DJ, Shen CP, Stribling DS, Rosko KM, et al. "Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N- [(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl] -2-methyl-2- [5-(trifluoromethyl)pyridin-2-yl] oxy] propanamide (MK-0364), in rodents." "Journal of Pharmacology and Experimental Therapeutics". 2007 Jun;321(3):1013-22. PMID 17327489. doi|10.1124/jpet.106.118737] It was discovered by Merck & Co.

In October 2008, Merck has stopped its phase III clinical trials with the drugs due to high level of central side effects, mainly depression and anxiety.cite web |url=http://www.merck.com/newsroom/press_releases/research_and_development/2008_1002.html |title=Press release by Merck |format= |work= |accessdate=October 2008]

References


Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Cannabinoid receptor antagonist — The discovery of the endogenous cannabinoid system led to the development of CB1 receptor antagonists. The first cannabinoid receptor antagonist, rimonabant, was described in 1994. Rimonabant blocks the CB1 receptor selectively and it has been… …   Wikipedia

  • obesity — o·be·si·ty (ō bēʹsĭ tē) n. The condition of being obese; increased body weight caused by excessive accumulation of fat. * * * Excessive body fat. It is usually caused by sedentary habits and a diet high in fat, alcohol, or total calories.… …   Universalium

  • Otenabant — Systematic (IUPAC) name 1 [8 (2 chlorophenyl) 9 (4 chlorophenyl) 9H purin 6 yl] 4 (ethylamino)piperidine 4 carboxamide Clinical data Pregnancy cat …   Wikipedia

  • Amphetamine — For other uses, see Amphetamine (disambiguation). Amphetamine Systematic (IUPAC) name …   Wikipedia

  • Tetrahydrocannabinol — THC redirects here. For other uses, see THC (disambiguation). Tetrahydrocannabinol (THC) …   Wikipedia

  • Stimulant — Ritalin Slow Release (SR) 20 mg tablets. Stimulants (also referred to as psychostimulants) are psychoactive drugs which induce temporary improvements in either mental or physical function or both. Examples of these kinds of effects may include… …   Wikipedia

  • Paracetamol — Acetaminophen Systematic (IUPAC) name …   Wikipedia

  • Anandamide — IUPAC name (5Z,8Z,11Z,14Z) N (2 hydroxyethyl)icosa 5,8,11,14 tetraenamide …   Wikipedia

  • Effects of cannabis — Short term effects of cannabis Classification and external resources ICD 10 F12.0 The effects of cannabis are caused by cannabinoids, most notably tetrahydrocannabinol (THC). Cannabis has both psychological and physiological effects on the human… …   Wikipedia

  • Benzphetamine — Systematic (IUPAC) name (2S) N benzyl N methyl 1 phenylpropan 2 amine …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”