Propacetamol

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IUPAC_name =(4-acetamidophenyl) 2-diethylaminoacetate

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ATC_prefix = N02
ATC_suffix = BE05
PubChem = 68865
C = 14 |H = 2 |N = 2 |O = 3
molecular_weight = 264.3202 g/mol
density =
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elimination_half-life = 2.4 hours cite journal |author=Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A |title=Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol |journal=Br J Clin Pharmacol |volume=34 |issue=1 |pages=79–81 |year=1992 |pmid=1633071 |doi=|accessdate=2008-04-01]
excretion = Renal
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routes_of_administration = IVcite journal |author=Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A |title=Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol |journal=Br J Clin Pharmacol |volume=34 |issue=1 |pages=79–81 |year=1992 |pmid=1633071 |doi= |accessdate=2008-04-01] cite journal |author=Binhas M, Decailliot F, Rezaiguia-Delclaux S, Suen P, Dumerat M, François V, Combes X, Duvaldestin P |title=Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplasty under remifentanil-based anesthesia: a randomized control trial [ISRCTN71723173] |journal=BMC Anesthesiol |volume=4 |issue=1 |pages=6 |year=2004 |pmid=15367329 |doi=10.1186/1471-2253-4-6 |url=http://www.biomedcentral.com/1471-2253/4/6 |accessdate=2008-04-01]

Propacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid Diethylglycin. This has the advantage of making it more water soluble. It is used in post-operative care and is delivered by I.V.. cite journal |author=Binhas M, Decailliot F, Rezaiguia-Delclaux S, Suen P, Dumerat M, François V, Combes X, Duvaldestin P |title=Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplasty under remifentanil-based anesthesia: a randomized control trial [ISRCTN71723173] |journal=BMC Anesthesiol |volume=4 |issue=1 |pages=6 |year=2004 |pmid=15367329 |doi=10.1186/1471-2253-4-6 |url=http://www.biomedcentral.com/1471-2253/4/6 |accessdate=2008-04-01] It is given if the patient is unable to take oral or rectally delivered paracetamol and non-steroidal anti-inflammatory drugs are contraindicated. The onset of analgaesia from propacetamol is more rapid than paracetamol is given orally.cite journal |author=Moller PL, Sindet-Pedersen S, Petersen CT, Juhl GI, Dillenschneider A, Skoglund LA |title=Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery |journal=Br J Anaesth |volume=94 |issue=5 |pages=642–8 |year=2005 |pmid=15790675 |doi=10.1093/bja/aei109 |url=http://bja.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=15790675 |accessdate=2008-04-04] 2g of propacetamol are equivalent to 1g of paracetamol. cite journal |author=Flouvat B, Leneveu A, Fitoussi S, Delhotal-Landes B, Gendron A |title=Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects |journal=Int J Clin Pharmacol Ther |volume=42 |issue=1 |pages=50–7 |year=2004 |pmid=14756388 |doi= |accessdate=2008-04-04]

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