NUFIP1

Nuclear fragile X mental retardation protein interacting protein 1
Identifiers
Symbols	NUFIP1; NUFIP; bA540M5.1
External IDs	OMIM: 604354 MGI: 1351474 HomoloGene: 8216 GeneCards: NUFIP1 Gene
Gene Ontology Molecular function • DNA binding • RNA binding • protein binding • zinc ion binding • snoRNA binding • protein binding, bridging • identical protein binding • metal ion binding Cellular component • intracellular • nucleus • perichromatin fibrils • nucleolus • transcription elongation factor complex • actin cytoskeleton • nuclear matrix • cytosolic ribosome • presynaptic active zone • pre-snoRNP complex Biological process • box C/D snoRNP assembly • RNA processing • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26747	27275
Ensembl	ENSG00000083635	ENSMUSG00000022009
UniProt	Q9UHK0	Q9QXX8
RefSeq (mRNA)	NM_012345	NM_013745.5
RefSeq (protein)	NP_036477	NP_038773.1
Location (UCSC)	Chr 13: 45.51 – 45.56 Mb	Chr 14: 76.51 – 76.54 Mb
PubMed search	[1]	[2]

Nuclear fragile X mental retardation-interacting protein 1 is a protein that in humans is encoded by the NUFIP1 gene.^[1][2][3]

Interactions

NUFIP1 has been shown to interact with FMR1,^[1][4] Cyclin T1^[5] and BRCA1.^[5]

References

1. ^ ^{a b} Bardoni B, Schenck A, Mandel JL (Jan 2000). "A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein". Hum Mol Genet 8 (13): 2557–66. doi:10.1093/hmg/8.13.2557. PMID 10556305. 
2. ^ Bardoni B, Giglio S, Schenck A, Rocchi M, Mandel JL (Aug 2000). "Assignment of NUFIP1 (nuclear FMRP interacting protein 1) gene to chromosome 13q14 and assignment of a pseudogene to chromosome 6q12". Cytogenet Cell Genet 89 (1–2): 11–3. doi:10.1159/000015580. PMID 10894927. 
3. ^ "Entrez Gene: NUFIP1 nuclear fragile X mental retardation protein interacting protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26747. 
4. ^ Bardoni, Barbara; Castets Marie, Huot Marc-Etienne, Schenck Annette, Adinolfi Salvatore, Corbin François, Pastore Annalisa, Khandjian Edouard W, Mandel Jean-Louis (Jul. 2003). "82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization". Hum. Mol. Genet. (England) 12 (14): 1689–98. doi:10.1093/hmg/ddg181. ISSN 0964-6906. PMID 12837692. 
5. ^ ^{a b} Cabart, Pavel; Chew Helen K, Murphy Shona (Jul. 2004). "BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II". Oncogene (England) 23 (31): 5316–29. doi:10.1038/sj.onc.1207684. ISSN 0950-9232. PMID 15107825. 

Further reading

• Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Cabart P, Chew HK, Murphy S (2004). "BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II". Oncogene 23 (31): 5316–29. doi:10.1038/sj.onc.1207684. PMID 15107825. 
• Dunham A, Matthews LH, Burton J et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2665288. 
• Bardoni B, Willemsen R, Weiler IJ et al. (2003). "NUFIP1 (nuclear FMRP interacting protein 1) is a nucleocytoplasmic shuttling protein associated with active synaptoneurosomes". Exp. Cell Res. 289 (1): 95–107. doi:10.1016/S0014-4827(03)00222-2. PMID 12941608. 
• Bardoni B, Castets M, Huot ME et al. (2003). "82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization". Hum. Mol. Genet. 12 (14): 1689–98. doi:10.1093/hmg/ddg181. PMID 12837692. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.