HERC5

Hect domain and RLD 5, also known as HERC5, is a human gene.cite web | title = Entrez Gene: HERC5 hect domain and RLD 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51191| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.cite web | title = Entrez Gene: HERC5 hect domain and RLD 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51191| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Salon C, Merdzhanova G, Brambilla C, "et al." |title=E2F-1, Skp2 and cyclin E oncoproteins are upregulated and directly correlated in high-grade neuroendocrine lung tumors. |journal=Oncogene |volume=26 |issue= 48 |pages= 6927-36 |year= 2007 |pmid= 17471231 |doi= 10.1038/sj.onc.1210499
*cite journal | author=Takeuchi T, Inoue S, Yokosawa H |title=Identification and Herc5-mediated ISGylation of novel target proteins. |journal=Biochem. Biophys. Res. Commun. |volume=348 |issue= 2 |pages= 473-7 |year= 2006 |pmid= 16884686 |doi= 10.1016/j.bbrc.2006.07.076
*cite journal | author=Wong JJ, Pung YF, Sze NS, Chin KC |title=HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 28 |pages= 10735-40 |year= 2006 |pmid= 16815975 |doi= 10.1073/pnas.0600397103
*cite journal | author=Dastur A, Beaudenon S, Kelley M, "et al." |title=Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells. |journal=J. Biol. Chem. |volume=281 |issue= 7 |pages= 4334-8 |year= 2006 |pmid= 16407192 |doi= 10.1074/jbc.M512830200
*cite journal | author=Hochrainer K, Mayer H, Baranyi U, "et al." |title=The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects. |journal=Genomics |volume=85 |issue= 2 |pages= 153-64 |year= 2005 |pmid= 15676274 |doi= 10.1016/j.ygeno.2004.10.006
*cite journal | author=Kroismayr R, Baranyi U, Stehlik C, "et al." |title=HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells. |journal=J. Cell. Sci. |volume=117 |issue= Pt 20 |pages= 4749-56 |year= 2005 |pmid= 15331633 |doi= 10.1242/jcs.01338
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Xu XR, Huang J, Xu ZG, "et al." |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089-94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398
*cite journal | author=Mitsui K, Nakanishi M, Ohtsuka S, "et al." |title=A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins. |journal=Biochem. Biophys. Res. Commun. |volume=266 |issue= 1 |pages= 115-22 |year= 2000 |pmid= 10581175 |doi= 10.1006/bbrc.1999.1777

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