Signal enhancement by extravascular water protons


Signal enhancement by extravascular water protons

Signal Enhancement by Extravascular water Protons, or SEEP, is a contrast mechanism for functional magnetic resonance imaging (fMRI), which is an alternative to the more commonly employed BOLD (blood-oxygen-level dependent) contrast. This mechanism for image contrast changes corresponding to changes in neuronal activity was first proposed by Dr. Patrick Stroman in 2001 (1, 2). SEEP contrast is based on changes in tissue water content which arise from the increased production of extracellular fluid (3, 4) and swelling of neurons and glial cells at sites of neuronal activity (5, 6). Because the dominant sources of MRI signal in biological tissues are water and lipids, an increase in tissue water content is reflected by a local increase in MR signal intensity. A correspondence between BOLD and SEEP signal changes, and sites of activity, has been observed in the brain and appears to arise from the common dependence on changes in local blood flow to cause a change in blood oxygenation or to produce extracellular fluid (7, 8). The advantage of SEEP contrast is that it can be detected with MR imaging methods which are relatively insensitive to magnetic susceptibility differences between air, tissues, blood, and bone. Such susceptibility differences can give rise to spatial image distortions and areas of low signal, and magnetic susceptibility changes in blood give rise to the BOLD contrast for fMRI. The primary application of SEEP to date has been fMRI of the spinal cord (spinal fMRI) because the bone/tissue interfaces around the spinal cord cause poor image quality with conventional fMRI methods. The disadvantages of SEEP compared to BOLD contrast are that it reveals more localized areas of activity, and in the brain the signal intensity changes are typically lower, and it can therefore be more difficult to detect (7-10).It is also controversial because it is not universally agreed to exist as a contrast mechanism for fMRI. [Cite journal
author = Jochimsen TH, Norris DG, Moller HE
title = Is there a change in water proton density associated with functional magnetic resonance imaging?
journal = Magn Reson Med
year = 2005
volume = 53
issue = 2
pages = 470–473
doi = 10.1002/mrm.20351
pmid = 15678536
url = http://www3.interscience.wiley.com/cgi-bin/abstract/109876754/ABSTRACT
] However, more recent studies have demonstrated changes in MRI signal corresponding with changes in neuronal activity in rat cortical tissue slices, in the absence of blood flow or changes in oxygenation, and neuronal activity and cellular swelling were corroborated by light-transmittance microscopy. [Cite journal
author = Stroman PW, Lee AS, Pitchers KK, Andrew RD
title = Magnetic resonance imaging of neuronal and glial swelling as an indicator of function in cerebral tissue slices
journal = Magn Reson Med
year = 2008
volume = 59
pages = 700–706
doi = 10.1002/mrm.21534
] This demonstrated SEEP contrast in the absence of confounding factors which can occur in-vivo, such as physiological motion and the possibility of concurrent BOLD contrast.

References

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# Stroman PW, Krause V, Malisza KL, Frankenstein UN, Tomanek B. Characterization of contrast changes in functional MRI of the human spinal cord at 1.5 T. Magn Reson Imaging 2001;19(6):833-838.
# Stroman PW, Krause V, Frankenstein UN, Malisza KL, Tomanek B. Spin-echo versus gradient-echo fMRI with short echo times. Magn Reson Imaging 2001;19(6):827-831.
# Cite journal
author = Ohta S, Meyer E, Fujita H, Reutens DC, Evans A, Gjedde A
title = Cerebral [15O] water clearance in humans determined by PET: I. Theory and normal values
journal = J Cereb Blood Flow Metab
year = 1996
volume = 16
issue = 5
pages = 765–780
doi = 10.1097/00004647-199609000-00002

# Fujita H, Meyer E, Reutens DC, Kuwabara H, Evans AC, Gjedde A. Cerebral [15O] water clearance in humans determined by positron emission tomography: II. Vascular responses to vibrotactile stimulation. J Cereb Blood Flow Metab 1997;17(1):73-79.
# Andrew RD, MacVicar BA. Imaging cell volume changes and neuronal excitation in the hippocampal slice. Neuroscience 1994;62(2):371-383.
# Andrew RD, Jarvis CR, Obeidat AS. Potential sources of intrinsic optical signals imaged in live brain slices. Methods 1999;18(2):185-96, 179.
# Stroman PW, Tomanek B, Krause V, Frankenstein UN, Malisza KL. Functional magnetic resonance imaging of the human brain based on signal enhancement by extravascular protons (SEEP fMRI). Magn Reson Med 2003;49(3):433-439.
# Stroman PW, Kornelsen J, Lawrence J, Malisza KL. Functional magnetic resonance imaging based on SEEP contrast: response function and anatomical specificity. Magn Reson Imaging 2005;23(8):843-850.
# Stroman PW, Krause V, Malisza KL, Frankenstein UN, Tomanek B. Extravascular proton-density changes as a non-BOLD component of contrast in fMRI of the human spinal cord. Magn Reson Med 2002;48(1):122-127.
# Stroman PW, Malisza KL, Onu M. Functional magnetic resonance imaging at 0.2 Tesla. NeuroImage 2003;20(2):1210-1214.


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  • Spinal fMRI — Functional magnetic resonance imaging (fMRI) of the spinal cord (spinal fMRI) is an adaptation of the fMRI method that has been developed for use in the brain (1). Although the basic principles underlying the methods are the same, spinal fMRI… …   Wikipedia


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