Codoxime

Codoxime

Systematic (IUPAC) name
(((4,5α- Epoxy- 3-methoxy- 17-methylmorphinan- 6-ylidene) amino)oxy) acetic acid
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	7125-76-0
ATC code	None
PubChem	CID 9570253
ChemSpider	7844721
UNII	JT5I2F57F7 Y
KEGG	D03581
Synonyms	Codoxime
Chemical data
Formula	C20H24N2O5
Mol. mass	372.415 g/mol
SMILES	eMolecules & PubChem

Codoxime (Codossima) is an opiate analogue that is a derivative of hydrocodone, where the 6-ketone group has been replaced by carboxymethyloxime. It has primarily antitussive effects^[1] and was found to have moderate potential to cause dependence in animal studies.^[2]

References

1. ^ Jack Fishman. Morphinone and Codeinone Derivatives. US Patent 3153042
2. ^ Jasinski DR, Martin WR. Assessment of the dependence-producing properties of dihydrocodeinone and codoxime. Clinical Pharmacology and Therapeutics. 1967 Mar-Apr;8(2):266-70. PMID 6021586

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