N-Phenethyl-14-ethoxymetopon

N-Phenethyl-14-ethoxymetopon

Systematic (IUPAC) name
(5α)-14-ethoxy- 3-hydroxy- 5-methyl- 17-(2-phenylethyl)- 4,5-epoxymorphinan- 6-one
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
ATC code	?
PubChem	CID 11049533
Chemical data
Formula	C27H31NO4
Mol. mass	433.538 g/mol
SMILES	eMolecules & PubChem
Y(what is this?)  (verify)

N-Phenethyl-14-ethoxymetopon is a drug which is a derivative of metopon. It is a potent analgesic, around 60 times stronger than morphine and produces significantly less constipation.^[1]

N-Phenethyl-14-ethoxymetopon acts as an agonist at both μ- and δ-opioid receptors, with a Ki of 0.16nM at μ and 3.14nM at δ.^[2]

See also

• 14-Cinnamoyloxycodeinone
• 14-Phenylpropoxymetopon
• 7-PET
• N-Phenethylnormorphine
• Phenomorphan
• RAM-378
• Ro4-1539

References

1. ^ Ananthan, S (2006). "Opioid ligands with mixed μ/δ opioid receptor interactions: An emerging approach to novel analgesics". The AAPS journal 8 (1): E118–25. doi:10.1208/aapsj080114. PMC 2751430. PMID 16584118. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2751430. 
2. ^ Lattanzi, R; Spetea, M; Schüllner, F; Rief, SB; Krassnig, R; Negri, L; Schmidhammer, H (2005). "Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities". Journal of medicinal chemistry 48 (9): 3372–8. doi:10.1021/jm040894o. PMID 15857143. 

This analgesic-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Delta-opioid agonists Morphinans Phenols Ketones Ethers Mu-opioid agonists Semisynthetic opioids Analgesic stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно решить контрольную? List of mergers in Chiba Prefecture Maëlys (given name) Look at other dictionaries: Opioid — Endogenous opioid peptides Skeletal molecular images Adrenorphin Amidorphin Casomorphin …   Wikipedia Opioid receptor — Opioid receptors are a group of G protein coupled receptors with opioids as ligands.[1][2][3] The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. The opioid receptors are 40% identical to somatostatin… …   Wikipedia PEPAP — Systematic (IUPAC) name 4 phenyl 1 (2 phenylethyl)piperidin 4 yl acetate Clinical data Pregnancy cat.  ? …   Wikipedia Arylcyclohexylamine — Phencyclidine, the prototypal arylcyclohexylamine derivative. Arylcyclohexylamines, also known as arylcyclohexamines or arylcyclohexanamines, are a chemical class of pharmaceutical, designer, and experimental drugs. Contents …   Wikipedia N-Phenethylnormorphine — Systematic (IUPAC) name 3,6 dihydroxy 7,8 didehydro 4,5α epoxy 17 (2 phenylethyl)morphinan Clinical data Pregnancy cat …   Wikipedia N-Phenethylnordesomorphine — Systematic (IUPAC) name 3 hydroxy 4,5α epoxy 17 (2 phenylethyl)morphinan Clinical data Pre …   Wikipedia Morphine — This article is about the drug. For other meanings, see Morphine (disambiguation). Morphia redirects here. For other uses, see Morphia (disambiguation). Not to be confused with Morphinae, Morphea, or Morpholine. Morphine …   Wikipedia Opiate — For other uses see Opiate (disambiguation), or for the class of drugs see Opioid. Harvesting the poppy pod. In medicine, the term opiate describes any of the narcotic opioid alkaloids found as natural products in the opium poppy plant …   Wikipedia Phencyclidine — Systematic (IUPAC) name …   Wikipedia Loperamide — Imodium redirects here. For the song by Nirvana, see Breed (song). Loperamide Systematic (IUPAC) name …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”