DOTFM

Drugbox
IUPAC_name = 1-(4-(trifluoromethyl)-2,5-dimethoxyphenyl)-2-aminopropane


width = 200
CAS_number=
ATC_prefix=
ATC_suffix=
PubChem= 10400521
DrugBank=
C=12 | H=16 | F=3 | N=1 | O=2
molecular_weight = 263.255 g/mol
smiles = COc1cc(C(F)(F)F)c(OC)cc1CC(N)C
bioavailability=
metabolism =
elimination_half-life=
excretion =
pregnancy_category =
legal_status =
routes_of_administration=

DOTFM is an analogue of the phenethylamine derived hallucinogen DOB where the bromine atom has been replaced by a trifluoromethyl group. It was discovered in 1994 by a team at Purdue University.

DOTFM is the amphetamine homolog of the phenethylamine hallucinogen 2C-TFM and is around twice as potent as 2C-TFM in animal studies. It acts as a potent agonist for the 5HT_2A and 5HT_2C receptors. In drug-substitution experiments in rats, DOTFM fully substituted for LSD and was slightly more potent than DOI. [Nichols DE, Frescas S, Marona-Lewicka D, Huang X, Roth BL, Gudelsky GA, Nash JF. 1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: a potent serotonin 5-HT2A/2C agonist. "Journal of Medicinal Chemistry". 1994 Dec 9;37(25):4346-51. PMID 7996545] Anecdotal reports from human users suggest that DOTFM is a potent hallucinogen with an extremely long duration of action, similar to Br-DFLY.

References