AMG-36

AMG-36

Drugbox
IUPAC_name = (6aR,10aR)-3-(1-hexylcyclopentyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo [c] chromen-1-ol


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CAS_number=
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PubChem= 10982174
DrugBank=
C=27 | H=40 | O=2
molecular_weight = 396.604 g/mol
smiles = CC2(C)Oc1cc(C4(CCCCCC)CCCC4)cc(O)c1C(C3)C2CC=C3C
bioavailability=
metabolism =
elimination_half-life=
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AMG-36 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC substituted with a cyclopentane group on the 3-position side chain. AMG-36 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.4nM at CB1 vs 1.9nM at CB2. [Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG, Makriyannis A. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. "Journal of Medicinal Chemistry". 2003 Jul 17;46(15):3221-9. PMID 12852753] [Papahatjis DP, Nahmias VR, Nikas SP, Andreou T, Alapafuja SO, Tsotinis A, Guo J, Fan P, Makriyannis A. C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols. "Journal of Medicinal Chemistry". 2007 Aug 23;50(17):4048-60. PMID 17672444]

References


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