C3a (complement)

C3a (complement): The classical and alternative complement pathways.

C3a is a one of the proteins formed by the cleavage of complement component 3; the other is C3b. It stimulates mast cell degranulation, thus triggering an immune response.

C3a plays an important role in chemotaxis, though not as important a role as C5a.^[1]

It is also an anaphylatoxin and the precursor of the important cytokine (adipokine) ASP through its interaction with carboxypeptidase B.^[2]

References

^ Immunology at MCG 1/phagocyt

^ Onat A, Can G, Rezvani R, Cianflone K. "Complement C3 and cleavage products in cardiometabolic risk". Complement C3 and cleavage products in cardiometabolic risk (Clin Chim Acta. 2011 Jun 11;412(13-14):1171-9. Epub 2011 Mar 15). PMID 21419112.

External links

http://www.merck.com/mmpe/sec13/ch163/ch163d.html

v · d · eProteins: complement system (C, L, A)

Activators/enzymes

Early

C: C1Q/C1R/C1S - C4 (C4a) - C2

L: MASP1/MASP2 - MBL
A: Factor B - Factor D - Factor P/Properdin

Middle

C3 (C3a, C3b/iC3b) - C5 (C5a)
C3-convertase - C5-convertase

Late

MAC (C6, C7, C8, C9)

Inhibitors

CLA: C1-inhibitor - Decay-accelerating factor/CD59 - Factor I

CL: C4BP
A: Factor H

Complement receptors
CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin (C3a, C5a)

M: LMC

cell/phys/auag/auab/comp, igrc

imdf/ipig/hyps/tumr

proc, drug(L3/4)

Categories:
Complement system
Immunology stubs

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