Cilnidipine

Cilnidipine
Cilnidipine
Systematic (IUPAC) name
O3-(2-methoxyethyl) O5-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine- 3,5-dicarboxylate
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 132203-70-4
ATC code C08CA14
PubChem CID 5282138
ChemSpider 4445338
UNII 97T5AZ1JIP YesY
KEGG D01173
Chemical data
Formula C27H28N2O7 
Mol. mass 492.52 g/mol
SMILES eMolecules & PubChem

Cilnidipine (INN) is a calcium channel blocker. It is sold as 'Atelec' in Japan, and as 'Cilacar' in India as 5 mg and 10 mg tablets.

Cilnidipine is a dual blocker of L-type voltage-gated calcium channels in vascular smooth muscle and N-type calcium channels in sympathetic nerve terminals that supply blood vessels. However, the clinical benefits of cilnidipine and underlying mechanisms are incompletely understood.

Clinidipine is the new type of calcium antagonist accompanied with L-type and N-type calcium channel blocking function. It was jointly developed by Fuji Viscera Pharmaceutical Company, Japan and Ajinomoto, Japan and approved to come into market for the first time and used for high blood pressure treatment in 1995. Compared with other calcium antagonists, clinidipine can act on the N-type calcium-channel that existing sympathetic nerve end besides acting on L-type calcium-channel that similar to most of the calcium antagonists.

External links

  • http://www.mcyy.com.cn/e-product2.asp[dead link]
  • Löhn M, Muzzulini U, Essin K, et al. (May 2002). "Cilnidipine is a novel slow-acting blocker of vascular L-type calcium channels that does not target protein kinase C". J. Hypertens. 20 (5): 885–93. PMID 12011649. 
v · d · eChannel blocker: calcium channel blockers (C08)
Selective
Dihydropyridines ("-dipine")
Amlodipine# • Aranidipine • Azelnidipine • Barnidipine • Benidipine • Cilnidipine • Clevidipine • Darodipine • Efonidipine • Felodipine • Isradipine • Lacidipine • Manidipine • Lercanidipine • Mepirodipine • Nicardipine • Nifedipine# • Niludipin • Nilvadipine • Nimodipine • Nisoldipine • Nitrendipine • Oxodipine • Pranidipine • Ryodipine
Phenylalkylamines ("-pamil")
Anipamil  • Devapamil • Emopamil • Falipamil  • Gallopamil • Norverapamil  • Verapamil
1-4 Benzothiazepines ("-tiazem")
Non-selective
Bepridil • Fendiline • Lidoflazine • Perhexiline
Other/ungrouped
Amrinone  • Anandamide  • Azimilide  • Bencyclane  • Berbamine  • Bevantolol • Canadine • Carboxyamidotriazole  • Caroverine  • Cinnarizine  • Conotoxins  • Dauricine  • Dimeditiapramine • Dotarizine • Enpiperate  • Eperisone • Fantofarone  • Fasudil  • Fenamic acid  • Flunarizine  • Fostedil • Gabapentin  • Lamotrigine  • Magnesium sulfate  • Manoalide • Mibefradil‡  • Monatepil  • Naftopidil  • Niguldipine  • Ochratoxin A • Octylonium  • Osthol  • Pinaverium  • Piperidine  • Pregabalin  • Prenylamine  • Risedronic acid • Sesamodil  • Stepholidine  • Terodiline  • Tetrahydropalmatine  • Tetrandrine  • Tolfenamic acid • Tranilast  • TROX-1  • Ziconotide
#WHO-EM. ‡Withdrawn from market. Clinical trials: †Phase III. §Never to phase III

M: VAS

anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug(C2s+n/3/4/5/7/8/9)
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