- Technetium (99mTc) exametazime
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Technetium (99mTc) exametazime 
Systematic (IUPAC) name [[(3RS,3'RS)-3,3'-[(2,2-Dimethyltrimethylene)diimino][di-2-butanone]dioximato](3-)-N,N',N'',N''']oxotechnetium (99mTc) Clinical data Licence data US FDA:link Pregnancy cat. ? Legal status ℞-only (US) Routes Intravenous Identifiers CAS number
100551-63-1 (exametazime)ATC code V09AA01
V09HA02 (labelled leucocytes)PubChem CID 9552069 Chemical data Formula C13H25N4O3Tc Mol. mass 384.3655 g/mol 
(what is this?) (99mTc) exametazime (verify)Technetium (99mTc) exametazime (trade name Ceretec) is a drug used for the detection of altered regional cerebral perfusion in stroke[1] and other cerebrovascular diseases, and for the labelling of leukocytes to localise intra-abdominal infections[2] and inflammatory bowel disease[3].
Chemistry
Exametazime (hexamethylpropyleneamine oxime, HMPAO)
The drug consists of two of the three stereoisomers of hexametazime (HMPAO), one of which is shown here, the other being its enantiomer.[4] The third stereoisomer is the meso form. Exametazime acts as a chelating agent for the radioisotope technetium-99m.
References
- ^ Moretti, J. L.; Defer, G.; Cinotti, L.; Cesaro, P.; Degos, J. D.; Vigneron, N.; Ducassou, D.; Holman, B. L. (1990). ""Luxury perfusion" with 99mTc-HMPAO and 123I-IMP SPECT imaging during the subacute phase of stroke". European journal of nuclear medicine 16 (1): 17–22. doi:10.1007/BF01566007. PMID 2307169.
- ^ Weldon, M. J.; Joseph, A. E.; French, A.; Saverymuttu, S. H.; Maxwell, J. D. (1995). "Comparison of 99m technetium hexamethylpropylene-amine oxime labelled leucocyte with 111-indium tropolonate labelled granulocyte scanning and ultrasound in the diagnosis of intra-abdominal abscess". Gut 37 (4): 557–564. doi:10.1136/gut.37.4.557. PMC 1382910. PMID 7489945. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1382910.
- ^ Ui, K.; Yamaguchi, T. (1991). "Therapy and diagnosis of emergency shock patients". Nihon Naika Gakkai zasshi. the Journal of the Japanese Society of Internal Medicine 80 (12): 1892–1896. PMID 1804909.
- ^ Monography in the European Pharmacopoeia
External links
Diagnostic radiopharmaceuticals (V09) Central nervous system Skeletal system 99mTc (Medronic acid)Renal 123I (Sodium iodohippurate)Hepatic/reticuloendothelial 75Se (SeHCAT)Respiratory system Cardiovascular system Inflammation/infection Tumor 99mTc (Arcitumomab • Votumumab • Hynic-octreotide) • 111In (Capromab pendetide • Satumomab pendetide) • 125I (CC49) • 123I/131I (Iobenguane) • 18F (Fludeoxyglucose, Sodium fluoride)Adrenal cortex Radionuclides
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