Mephenytoin

Mephenytoin

Systematic (IUPAC) name
5-ethyl-3-methyl-5-phenyl-imidazolidine-2,4-dione
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a611020
Pregnancy cat.	C(US)
Legal status	?
Routes	Oral
Pharmacokinetic data
Half-life	7 hours
Identifiers
CAS number	50-12-4 Y
ATC code	N03AB04
PubChem	CID 4060
DrugBank	APRD00512
ChemSpider	3920 Y
UNII	R420KW629U Y
KEGG	D00375 Y
ChEMBL	CHEMBL861 Y
Chemical data
Formula	C12H14N2O2
Mol. mass	218.252
SMILES	eMolecules & PubChem
InChI InChI=1S/C12H14N2O2/c1-3-12(9-7-5-4-6-8-9)10(15)14(2)11(16)13-12/h4-8H,3H2,1-2H3,(H,13,16) Y Key:GMHKMTDVRCWUDX-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Mephenytoin (marketed as Mesantoin by Novartis) is a hydantoin, used as an anticonvulsant. It was introduced approximately 10 years after phenytoin, in the late 1940s. The significant metabolite of mephenytoin is nirvanol (5-ethyl-5-phenylhydantoin), which was the first hydantoin (briefly used as a hypnotic). However, nirvanol is quite toxic and mephenytoin was only considered after other less toxic anticonvulsants had failed. It can cause potentially fatal blood dyscrasia in 1% of patients.

Mephenytoin is no longer available in the US or the UK. It is still studied largely because of its interesting hydroxylation polymorphism.

References

• The Treatment of Epilepsy edited by S. D. Shorvon, David R. Fish, Emilio Perucca, W. Edwin Dodson. Blackwell Publishing. 2004. ISBN 0-632-06046-8
• The Medical Treatment of Epilepsy by Stanley R Resor. Published by Marcel Dekker (1991). ISBN 0-8247-8549-5.
• The Comparative Toxicogenomics Database: Mephenytoin

This anticonvulsant-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Anticonvulsants Hydantoins Anticonvulsant stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать курсовую Greatheart Silver Arlene Alda Look at other dictionaries: mephenytoin — noun A hydantoin used as an anticonvulsant …   Wiktionary mephenytoin — An anticonvulsant used when safer agents prove inadequate; used in drug metabolism studies. * * * me·phen·y·to·in mə fen i .tō ən n an anticonvulsant drug C12H14N2O2 see MESANTOIN * * * me·phen·y·to·in (mə fenґə …   Medical dictionary mephenytoin — noun a toxic anticonvulsant drug (trade name Mesantoin) used in the treatment of epilepsy when less toxic anticonvulsants have been ineffective • Syn: ↑Mesantoin • Usage Domain: ↑trade name (for: ↑Mesantoin) • Hypernyms: ↑ …   Useful english dictionary CYP2C19 — Cytochrome P450 2C19 (abbreviated CYP2C19), a member of the cytochrome P450 mixed function oxidase system, is involved in the metabolism of xenobiotics in the body. It is involved in the metabolism of several important groups of drugs including… …   Wikipedia Phenytoin — Systematic (IUPAC) name 5,5 diphenylimidazolidine …   Wikipedia ATC code N03 — A section of the Anatomical Therapeutic Chemical Classification System.N Nervous systemN03A AntiepilepticsN03AA Barbiturates and derivatives:N03AA01 Methylphenobarbital:N03AA02 Phenobarbital:N03AA03 Primidone:N03AA04 Barbexaclone:N03AA30… …   Wikipedia Primidone — Systematic (IUPAC) name 5 ethyl 5 phenyl hexahydropyrimidine 4,6 dione Clinical data Pregnancy cat. D …   Wikipedia Fosphenytoin — Systematic (IUPAC) name (2,5 dioxo 4,4 diphenyl imidazolidin 1 yl)me …   Wikipedia Mesantoin — Mes·an·to·in mes an tō in trademark used for a preparation of mephenytoin * * * Me·san·to·in (mə sanґtoin) trademark for a preparation of mephenytoin …   Medical dictionary Benzodiazepine — Benzodiazepines …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”