Guanylyl cyclase c

Guanylyl cyclase c

protein
Name=guanylate cyclase 2C (heat stable enterotoxin receptor)
caption=


width=
HGNCid=4688
Symbol=GUCY2C
AltSymbols=GUC2C
EntrezGene=2984
OMIM=601330
RefSeq=NM_004963
UniProt=P25092
PDB=
ECnumber=4.6.1.2
Chromosome=12
Arm=p
Band=12
LocusSupplementaryData=

Guanylyl cyclase c, or GC-C, is an enzyme found only in the lumen|luminal aspect of intestinal epithelium. The receptor has an extracellular ligand-binding domain, a single transmembrane region, a region with sequence similar to that of protein kinases, and a C-terminal guanylyl cyclase domain. Tyrosine kinase activity mediates the GC-C signaling pathway within the cell.

Functions

GC-C is a key receptor for heat-stable enterotoxins which are responsible for acute secretory diarrhea. Heat-stable enterotoxins are produced by pathogens such as "Escherichia coli". Knockout mice defficient in the GC-C gene do not show secretory diarrhea on infection with "E. coli", though they do with cholera toxin. This demonstrates the specificity of the GC-C receptor.

Diagnostic application

Because GC-C is tissue-specific for intestinal epithelium, it can be used for exceedingly precise detection of metastatic disease. The presence of GC-C mRNA can be detected at a rate of a single cancer cell out of 10,000,000 normal cells. This is the most precise staging tool available.

ee also

* guanylate cyclase

External links

* [http://www.tdtinc.com/t_prod_blood.html GC-C testing for recurrent colorectal cancer]
* [http://www.jci.org/cgi/content/abstract/100/6/1590 GC-C knock-out mice]
*


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • Cyclase — A cyclase is an enzyme, almost always a lyase, that catalyzes a chemical reaction to form a cyclic compound. Important cyclase enzymes include: Adenylyl cyclase, which forms cyclic AMP from adenosine triphosphate Guanylyl cyclase, which forms… …   Wikipedia

  • guanylyl — The radical of guanylic acid. g. cyclase SYN: guanylate cyclase. * * * gua·nyl·yl (gwah nilґəl) the radical formed by removal of OH from the phosphate group of guanosine monophosphate …   Medical dictionary

  • Guanylate cyclase — (EC 4.6.1.2, also known as guanylyl cyclase, guanyl cyclase or GC) is a lyase enzyme. Contents 1 Reaction 2 Types 3 Function …   Wikipedia

  • guanylate cyclase — Analogous to adenylate (adenylyl) cyclase, but cyclizing guanosine 5′ triphosphate to guanosine 3′:5′ cyclic monophosphate and also producing pyrophosphate; activated by nitric oxide. SYN: guanyl cyclase, guanylyl cyclase. * * * gua·nyl·ate… …   Medical dictionary

  • NUCLÉOTIDES CYCLIQUES — La découverte de l’AMP cyclique, en 1956, a marqué une très grande étape dans l’histoire récente de la biologie. Pour la première fois, on pouvait comprendre et reproduire dans le tube à essai le mécanisme moléculaire de l’action d’une hormone,… …   Encyclopédie Universelle

  • NPR2 — Natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) Identifiers Symbols NPR2; AMDM; ANPRB; ANPb; GUC2B; GUCY2B; NPRB; NPRBi External IDs …   Wikipedia

  • GUCY1B3 — Guanylate cyclase 1, soluble, beta 3, also known as GUCY1B3, is a human gene.cite web | title = Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • GUCY1A2 — Guanylate cyclase 1, soluble, alpha 2, also known as GUCY1A2, is a human gene.cite web | title = Entrez Gene: GUCY1A2 guanylate cyclase 1, soluble, alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • NPR1 — Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) Identifiers Symbols NPR1; ANPRA; ANPa; GUC2A; GUCY2A; NPRA External IDs …   Wikipedia

  • Atrial natriuretic peptide receptor — A atrial natriuretic peptide receptor is a receptor for atrial natriuretic peptide.[1] Contents 1 Mechanism 2 Types 3 References …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”