Pantothenate kinase

Pantothenate kinase

Pantothenate kinase (PanK; CoaA) is the first enzyme in the Coenzyme A biosynthetic pathway. It phophorylates pantothenate (vitamin B5) to form 4'-phosphopantothenate.

Types

Three distinct types of PanK has been identified - PanK-I (found in bacteria), PanK-II (mainly found in eukaryotes, but also in the Staphylococci) and PanK-III, also known as CoaX (found in bacteria). Eukaryotic PanK-II enzymes often occur as different isoforms, such as PanK1, PanK2, PanK3 and PanK4.

Genes

PANK2 is associated with Pantothenate kinase-associated neurodegeneration, formerly called Hallervorden-Spatz syndrome. it also leads to brain fever and finally leads to death

External links

2.7.6: diphosphotransferase
(P2O7) 2.7.7: nucleotidyltransferase
(PO4-nucleoside) 2.7.8: miscellaneous 2.7.10-2.7.13: protein kinase
(PO4; protein acceptor)
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

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