NCK1

NCK1
NCK adaptor protein 1

PDB rendering based on 2ci8.
Identifiers
Symbols NCK1; MGC12668; NCK; NCKalpha; nck-1
External IDs OMIM600508 MGI109601 HomoloGene38148 GeneCards: NCK1 Gene
RNA expression pattern
PBB GE NCK1 204725 s at tn.png
PBB GE NCK1 211063 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4690 17973
Ensembl ENSG00000158092 ENSMUSG00000032475
UniProt P16333 n/a
RefSeq (mRNA) NM_001190796.1 NM_010878.2
RefSeq (protein) NP_001177725.1 NP_035008.2
Location (UCSC) Chr 3:
136.58 – 136.67 Mb
Chr 9:
100.39 – 100.45 Mb
PubMed search [1] [2]

Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.[1][2]

The Nck(non-catalytic region of tyrosine kinase adaptor protein 1)Protein belongs to the adaptor family of proteins.The nck gene was initially isolated from a human melanoma cDNA library using a monoclonal antibody produced against the human melanoma-associated antigen. The Nck family has two known members in human cells (Nck-1/Nckalpha and NcK2/NcKbeta), two in mouse cells (mNckalpha and mNckbeta/Grb4) and one in drosophila (Dock means dreadlocks-ortholog). The two murine gene products exhibit 68% aminoacid identity to one another,with most of the sequence variation being located to the linker regions between the SH3 and SH2 domains, and are 96% identical to their human counterparts. While human nck-1 gene has been localised to the 3q21 locus of chromosome 3, the nck-2 gene can be found on chromosome 2 at the 2q12 locus. The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS.[3]

Contents

Interactions

NCK1 has been shown to interact with DNM1,[4] EIF2B2,[5] KHDRBS1,[6][7] Lymphocyte cytosolic protein 2,[8][9] EPH receptor B1,[10] SOCS7,[11] MINK1,[12] MAP4K1,[13][14][15] MAP4K4,[16] Abl gene,[17][18] WIPF1,[19] RRAS,[20] Wiskott-Aldrich syndrome protein,[21][22][23] Epidermal growth factor receptor,[6][24][25] PDGFRB,[24][25] PTK2,[26][27] NCKIPSD,[28] RICS,[29] Cbl gene,[17][30] TANK-binding kinase 1,[31] SOS1,[4][25][32][33] Dystroglycan,[34] PAK1,[25][35][36] PKN2,[25][37] NEDD9,[26] WASL[38] and RASA1.[39]

See also

References

  1. ^ Huebner K, Kastury K, Druck T, Salcini AE, Lanfrancone L, Pelicci G, Lowenstein E, Li W et al. (Jan 1995). "Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2)". Genomics 22 (2): 281–7. doi:10.1006/geno.1994.1385. PMID 7806213. 
  2. ^ Chen M, She H, Davis EM, Spicer CM, Kim L, Ren R, Le Beau MM, Li W (Oct 1998). "Identification of Nck family genes, chromosomal localization, expression, and signaling specificity". J Biol Chem 273 (39): 25171–8. doi:10.1074/jbc.273.39.25171. PMID 9737977. 
  3. ^ "Entrez Gene: NCK1 NCK adaptor protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4690. 
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  39. ^ Ger, M; Zitkus Z, Valius M (Oct. 2011). "Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity". Cell. Signal. (ENGLAND) 23 (10): 1651–8. doi:10.1016/j.cellsig.2011.05.019. ISSN 0898-6568. PMID 21664272. 

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