PDCD6IP

PDCD6IP
Programmed cell death 6 interacting protein

PDB rendering based on 2oev.
Identifiers
Symbols PDCD6IP; AIP1; Alix; DRIP4; HP95; MGC17003
External IDs OMIM608074 MGI1333753 HomoloGene22614 GeneCards: PDCD6IP Gene
RNA expression pattern
PBB GE PDCD6IP 217746 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10015 18571
Ensembl ENSG00000170248 ENSMUSG00000032504
UniProt Q8WUM4 Q3TED2
RefSeq (mRNA) NM_001162429.1 NM_011052
RefSeq (protein) NP_001155901.1 NP_035182
Location (UCSC) Chr 3:
33.84 – 33.91 Mb
Chr 9:
113.56 – 113.62 Mb
PubMed search [1] [2]

Programmed cell death 6-interacting protein is a protein that in humans is encoded by the PDCD6IP gene.[1][2]

This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death.[2]

Interactions

PDCD6IP has been shown to interact with PDCD6.[1][3]

References

  1. ^ a b Vito P, Pellegrini L, Guiet C, D'Adamio L (Feb 1999). "Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction". J Biol Chem 274 (3): 1533–40. doi:10.1074/jbc.274.3.1533. PMID 9880530. 
  2. ^ a b "Entrez Gene: PDCD6IP programmed cell death 6 interacting protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10015. 
  3. ^ Satoh, Hirokazu; Shibata Hideki, Nakano Yoshimi, Kitaura Yasuyuki, Maki Masatoshi (Mar. 2002). "ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner". Biochem. Biophys. Res. Commun. (United States) 291 (5): 1166–72. doi:10.1006/bbrc.2002.6600. ISSN 0006-291X. PMID 11883939. 

Further reading


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