DNM1L

DNM1L
Dynamin 1-like
Identifiers
Symbols DNM1L; DLP1; DRP1; DVLP; DYMPLE; DYNIV-11; FLJ41912; HDYNIV; VPS1
External IDs OMIM603850 MGI1921256 HomoloGene6384 GeneCards: DNM1L Gene
EC number 3.6.5.5
RNA expression pattern
PBB GE DNM1L 203105 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10059 74006
Ensembl ENSG00000087470 ENSMUSG00000022789
UniProt O00429 Q3U4P3
RefSeq (mRNA) NM_005690.3 NM_001025947
RefSeq (protein) NP_005681.2 NP_001021118
Location (UCSC) Chr 12:
32.83 – 32.91 Mb
Chr 16:
16.31 – 16.36 Mb
PubMed search [1] [2]

Dynamin-1-like protein is a protein that in humans is encoded by the DNM1L gene.[1][2][3]

Contents

Function

The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm, possibly by control of mitochondrial fission. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.[3]

Interactions

DNM1L has been shown to interact with GSK3B[2] and FIS1.[4]

References

  1. ^ Shin HW, Shinotsuka C, Torii S, Murakami K, Nakayama K (Feb 1998). "Identification and subcellular localization of a novel mammalian dynamin-related protein homologous to yeast Vps1p and Dnm1p". J Biochem 122 (3): 525–30. PMID 9348079. 
  2. ^ a b Hong YR, Chen CH, Cheng DS, Howng SL, Chow CC (Oct 1998). "Human dynamin-like protein interacts with the glycogen synthase kinase 3beta". Biochem Biophys Res Commun 249 (3): 697–703. doi:10.1006/bbrc.1998.9253. PMID 9731200. 
  3. ^ a b "Entrez Gene: DNM1L dynamin 1-like". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10059. 
  4. ^ Yoon Y, Krueger EW, Oswald BJ, McNiven MA (August 2003). "The Mitochondrial Protein hFis1 Regulates Mitochondrial Fission in Mammalian Cells through an Interaction with the Dynamin-Like Protein DLP1". Mol. Cell. Biol. 23 (15): 5409–20. doi:10.1128/MCB.23.15.5409-5420.2003. PMC 165727. PMID 12861026. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=165727. 

Further reading


Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”