DYRK1B

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
Identifiers
Symbols	DYRK1B; MIRK
External IDs	OMIM: 604556 MGI: 1330302 HomoloGene: 31253 GeneCards: DYRK1B Gene
EC number	2.7.12.1
Gene Ontology Molecular function • nucleotide binding • transcription coactivator activity • protein kinase activity • protein serine/threonine kinase activity • protein tyrosine kinase activity • protein binding • ATP binding Cellular component • nucleus • nucleolus • intracellular membrane-bounded organelle Biological process • protein phosphorylation • myoblast fusion • positive regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9149	13549
Ensembl	ENSG00000105204	ENSMUSG00000002409
UniProt	Q9Y463	n/a
RefSeq (mRNA)	NM_004714.1	XM_992180
RefSeq (protein)	NP_004705.1	XP_997274
Location (UCSC)	Chr 19: 40.32 – 40.32 Mb	Chr 7: 28.96 – 28.97 Mb
PubMed search	[1]	[2]

Dual specificity tyrosine-phosphorylation-regulated kinase 1B is an enzyme that in humans is encoded by the DYRK1B gene.^[1][2]

Function

DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain.^[2]

Interactions

DYRK1B has been shown to interact with PCBD1^[3] and RANBP9.^[4]

References

1. ^ Leder S, Weber Y, Altafaj X, Estivill X, Joost HG, Becker W (Feb 1999). "Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases". Biochem Biophys Res Commun 254 (2): 474–9. doi:10.1006/bbrc.1998.9967. PMID 9918863. 
2. ^ ^{a b} "Entrez Gene: DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9149. 
3. ^ Lim, Seunghwan; Jin Kideok, Friedman Eileen (Jul. 2002). "Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha". J. Biol. Chem. (United States) 277 (28): 25040–6. doi:10.1074/jbc.M203257200. ISSN 0021-9258. PMID 11980910. 
4. ^ Zou, Yonglong; Lim Seunghwan, Lee Kangmoon, Deng Xiaobing, Friedman Eileen (Dec. 2003). "Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M". J. Biol. Chem. (United States) 278 (49): 49573–81. doi:10.1074/jbc.M307556200. ISSN 0021-9258. PMID 14500717. 

Further reading

• Mercer SE, Friedman E (2006). "Mirk/Dyrk1B: a multifunctional dual-specificity kinase involved in growth arrest, differentiation, and cell survival.". Cell Biochem. Biophys. 45 (3): 303–15. doi:10.1385/CBB:45:3:303. PMID 16845176. 
• Lee K, Deng X, Friedman E (2000). "Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.". Cancer Res. 60 (13): 3631–7. PMID 10910078. 
• Lim S, Jin K, Friedman E (2002). "Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha.". J. Biol. Chem. 277 (28): 25040–6. doi:10.1074/jbc.M203257200. PMID 11980910. 
• Lim S, Zou Y, Friedman E (2003). "The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase.". J. Biol. Chem. 277 (51): 49438–45. doi:10.1074/jbc.M206840200. PMID 12384504. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Zou Y, Lim S, Lee K, et al. (2004). "Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.". J. Biol. Chem. 278 (49): 49573–81. doi:10.1074/jbc.M307556200. PMID 14500717. 
• Skurat AV, Dietrich AD (2004). "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases.". J. Biol. Chem. 279 (4): 2490–8. doi:10.1074/jbc.M301769200. PMID 14593110. 
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824. 
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Deng X, Ewton DZ, Mercer SE, Friedman E (2005). "Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation.". J. Biol. Chem. 280 (6): 4894–905. doi:10.1074/jbc.M411894200. PMID 15546868. 
• Mercer SE, Ewton DZ, Deng X, et al. (2005). "Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts.". J. Biol. Chem. 280 (27): 25788–801. doi:10.1074/jbc.M413594200. PMC 1201501. PMID 15851482. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1201501. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Deng X, Ewton DZ, Li S, et al. (2006). "The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma.". Cancer Res. 66 (8): 4149–58. doi:10.1158/0008-5472.CAN-05-3089. PMID 16618736. 
• Takahashi-Yanaga F, Mori J, Matsuzaki E, et al. (2007). "Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells.". J. Biol. Chem. 281 (50): 38489–97. doi:10.1074/jbc.M605205200. PMID 17046823.