MUTED

Muted homolog (mouse)
Identifiers
Symbols	MUTED; DKFZp686E2287; FLJ18427; MU
External IDs	OMIM: 607289 MGI: 2178598 HomoloGene: 16374 GeneCards: MUTED Gene
Gene Ontology Molecular function • protein binding Cellular component • BLOC-1 complex Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	63915	17828
Ensembl	ENSG00000188428	ENSMUSG00000038982
UniProt	Q8TDH9	Q8R015
RefSeq (mRNA)	NM_001199322.1	NM_139063.1
RefSeq (protein)	NP_001186251.1	NP_620702.1
Location (UCSC)	Chr 6: 7.88 – 8.06 Mb	Chr 13: 38.68 – 38.73 Mb
PubMed search	[1]	[2]

Protein Muted homolog is a protein that in humans is encoded by the MUTED gene.^[1][2]

This gene encodes a component of BLOC-1 (biogenesis of lysosome-related organelles complex 1). Components of this complex are involved in the biogenesis of organelles such as melanosomes and platelet-dense granules. A mouse model for Hermansky-Pudlak syndrome is mutated in the murine version of this gene. Some transcripts of the downstream gene TXNDC5 overlap this gene, but they do not contain an open reading frame for this gene.^[2]

Interactions

MUTED has been shown to interact with BLOC1S2,^[3] Dysbindin^[3] and PLDN.^[3][4]

References

1. ^ Zhang Q, Li W, Novak EK, Karim A, Mishra VS, Kingsmore SF, Roe BA, Suzuki T, Swank RT (Mar 2002). "The gene for the muted (mu) mouse, a model for Hermansky-Pudlak syndrome, defines a novel protein which regulates vesicle trafficking". Hum Mol Genet 11 (6): 697–706. doi:10.1093/hmg/11.6.697. PMC 2847475. PMID 11912185. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2847475. 
2. ^ ^{a b} "Entrez Gene: MUTED muted homolog (mouse)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=63915. 
3. ^ ^{a b c} Starcevic, Marta; Dell'Angelica Esteban C (Jul. 2004). "Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)". J. Biol. Chem. (United States) 279 (27): 28393–401. doi:10.1074/jbc.M402513200. ISSN 0021-9258. PMID 15102850. 
4. ^ Falcón-Pérez, Juan M; Starcevic Marta, Gautam Rashi, Dell'Angelica Esteban C (Aug. 2002). "BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules". J. Biol. Chem. (United States) 277 (31): 28191–9. doi:10.1074/jbc.M204011200. ISSN 0021-9258. PMID 12019270. 

Further reading

• Falcón-Pérez JM, Starcevic M, Gautam R, Dell'Angelica EC (2002). "BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules.". J. Biol. Chem. 277 (31): 28191–9. doi:10.1074/jbc.M204011200. PMID 12019270. 
• Moriyama K, Bonifacino JS (2003). "Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles.". Traffic 3 (9): 666–77. doi:10.1034/j.1600-0854.2002.30908.x. PMID 12191018. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ciciotte SL, Gwynn B, Moriyama K, et al. (2003). "Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1).". Blood 101 (11): 4402–7. doi:10.1182/blood-2003-01-0020. PMID 12576321. 
• Li W, Zhang Q, Oiso N, et al. (2003). "Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).". Nat. Genet. 35 (1): 84–9. doi:10.1038/ng1229. PMC 2860733. PMID 12923531. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2860733. 
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
• Starcevic M, Dell'Angelica EC (2004). "Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1).". J. Biol. Chem. 279 (27): 28393–401. doi:10.1074/jbc.M402513200. PMID 15102850. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 

This protein-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Human proteins Protein stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Izvorul cu Paltin River GALNT11 Look at other dictionaries: muted — adj. 1. same as {quiet}; as, the muted atmosphere of a church. Opposite of {noisy}. Syn: hushed. [WordNet 1.5] 2. softened; rendered less loud or harsh; of sounds and instruments which produce sounds; as, muted trumpets. Syn: dull, muffled,… …   The Collaborative International Dictionary of English muted — (adj.) 1861, in reference to musical instruments, pp. adjective from MUTE (Cf. mute) (v.). Figuratively by 1879. Of colors by 1939. Related: mutedness …   Etymology dictionary muted — mut|ed [ˈmju:tıd] adj [usually before noun] 1.) muted sounds, voices etc are quieter than usual = ↑subdued ▪ Everyone was sitting round discussing the accident in muted voices. 2.) a muted reaction to something is not expressed strongly ▪ There… …   Dictionary of contemporary English muted — adjective 1 muted criticism/support/response etc criticism etc that is not expressed strongly: At first, criticism of the war was fairly muted. 2 quieter than usual: We could hear the muted cries of newspaper sellers in the street outside. 3 a… …   Longman dictionary of contemporary English muted — mut|ed [ mjutəd ] adjective not as strong or extreme as usual: Initial public reaction has been muted. a. not as loud as usual: the muted sound of distant thunder b. not as bright or colorful as usual: A muted light came from the second story …   Usage of the words and phrases in modern English muted — [[t]mju͟ːtɪd[/t]] ADJ GRADED: usu ADJ n Muted colours are soft and gentle, not bright and strong. He likes sombre, muted colours she likes bright colours... The muted greens of the far pasture …   English dictionary muted — UK [ˈmjuːtɪd] / US [ˈmjutəd] adjective not as strong or extreme as usual Initial public reaction has been muted. a) not as bright or colourful as usual A muted light came from the second storey. b) not as loud as usual the muted sound of distant… …   English dictionary muted — /ˈmjutəd/ (say myoohtuhd) adjective 1. low in intensity: muted colours; muted sounds. 2. restrained: a muted response …   muted — adj. VERBS ▪ be, seem, sound ▪ remain ADVERB ▪ extremely, fairly, very, etc …   Collocations dictionary muted — adjective 1) the muted hum of traffic Syn: muffled, faint, indistinct, quiet, soft, low 2) muted colors Syn: subdued, pastel, delicate, subtle, understated, restrained …   Thesaurus of popular words 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”