P53 p63 p73 family

P53 family

The p53 p63 p73 family is a family of tumor suppressor genes.^[1][2]

It consists of:

• p53
• TP73L (also known as "p63")
• p73

They are sometimes considered part of a "p53 family".^[3]

Evolution of the p53 family

P53, p63, and p73 have similar features in their gene structures and functions but have also diverged evolutionarily. The p53 family evolved from a p63/p73 ancestor gene in invertebrates. ^[4] P53 diverged from p63/p73 with a gene duplication in the cartilaginous fish. ^[4] P63 and p73 differentiated from each other in bony fish. ^[4]. These genes developed different functions and structures throughout their evolutionary divergence (TP73L, p73, p53) .

References

1. ^ Levrero M, De Laurenzi V, Costanzo A, Gong J, Wang JY, Melino G (May 2000). "The p53/p63/p73 family of transcription factors: overlapping and distinct functions". J. Cell. Sci. 113 ( Pt 10): 1661–70. PMID 10769197. http://jcs.biologists.org/cgi/pmidlookup?view=long&pmid=10769197. 
2. ^ Caleb Ellicott Finch (2007). The biology of human longevity: inflammation, nutrition, and aging in the evolution of lifespans. Academic Press. pp. 350–. ISBN 9780123736574. http://books.google.com/books?id=4rGOLEOC4mEC&pg=PA350. Retrieved 23 December 2010. 
3. ^ Chen S, Moroi Y, Urabe K, et al. (July 2008). "Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget's disease". Clin. Exp. Dermatol. 33 (5): 634–40. doi:10.1111/j.1365-2230.2008.02851.x. PMID 18627398. 
4. ^ ^{a b c} Levine, A. J., V. A. Belyi, P. Ak, E. Markert, H. J. Wang, W. W. Hu, and A. Puzio-Kuter. (2010). "The origins and evolution of the p53 family of genes". Cold Spring Harbor Perspectives in Biology 2.