Canbisol

Canbisol
Canbisol
Systematic (IUPAC) name
(6aR,9R,10aR)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,8,9,10,10a-hexahydrobenzo[c]chromene-1,9-diol
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 56689-43-1
ATC code  ?
PubChem CID 41969
UNII NZ1ZPC4WSF YesY
Chemical data
Formula C24H38O3 
Mol. mass 374.555 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Canbisol (HU-243), marketed under the name Nabidrox, is a synthetic cannabinoid derivative which is the dimethylheptyl homologue of 9-nor-9β-hydroxyhexahydrocannabinol (HHC). It is a potent agonist at both the CB1 and CB2 receptors, with a binding affinity of 0.1nM at CB1 and 0.2nM at CB2.[1] It is mainly used in scientific research, in receptor binding studies to determine the structure and function of the cannabinoid receptors,[2][3][4] but has been made illegal in some countries due to its possible abuse potential as a cannabinomimetic drug.[5]

See also

References

  1. ^ Rhee MH, Vogel Z, Barg J, Bayewitch M, Levy R, Hanus L, Breuer A, Mechoulam R (September 1997). "Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase". Journal of Medicinal Chemistry 40 (20): 3228–33. doi:10.1021/jm970126f. PMID 9379442. 
  2. ^ Rhee MH, Nevo I, Bayewitch ML, Zagoory O, Vogel Z (December 2000). "Functional role of tryptophan residues in the fourth transmembrane domain of the CB(2) cannabinoid receptor". Journal of Neurochemistry 75 (6): 2485–91. PMID 11080201. 
  3. ^ Rhee MH (September 2002). "Functional role of serine residues of transmembrane dopamin VII in signal transduction of CB2 cannabinoid receptor". Journal of Veterinary Science 3 (3): 185–91. PMID 12514330. 
  4. ^ Zhang R, Hurst DP, Barnett-Norris J, Reggio PH, Song ZH (July 2005). "Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template". Molecular Pharmacology 68 (1): 69–83. doi:10.1124/mol.104.007823. PMID 15840841. 
  5. ^ The Misuse of Drugs Act 1971 (Amendment) Order 2009
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