Org 28611

Org 28611

Systematic (IUPAC) name
[1-(cyclohexylmethyl)-7-methoxyindol-3-yl]-[(3S)-3,4-dimethylpiperazin-1-yl]methanone
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
ATC code	?
PubChem	CID 10091392
ChemSpider	8266929 Y
ChEMBL	CHEMBL1209709
Chemical data
Formula	C23H33N3O2
Mol. mass	383.526 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C23H33N3O2/c1-17-14-25(13-12-24(17)2)23(27)20-16-26(15-18-8-5-4-6-9-18)22-19(20)10-7-11-21(22)28-3/h7,10-11,16-18H,4-6,8-9,12-15H2,1-3H3/t17-/m0/s1 Y Key:ONXJNAIZJKLJGA-KRWDZBQOSA-N Y
Y(what is this?)  (verify)

Org 28611 (SCH-900,111) is a drug developed by Organon International which acts as a potent cannabinoid receptor full agonist at both the CB₁ and CB₂ receptors. It was developed with the aim of finding a water soluble cannabinoid agonist suitable for intravenous use as an analgesic,^[1] and while it achieved this aim and has progressed as far as Phase II clinical trials in humans as both a sedative and an analgesic, results against the comparison drugs (midazolam and morphine respectively) were not particularly favourable in initial testing.^[2][3]

See also

• Org 28312
• N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide

References

1. ^ Adam, J. M.; Cairns, J.; Caulfield, W.; Cowley, P.; Cumming, I.; Easson, M.; Edwards, D.; Ferguson, M. et al. (2010). "Design, synthesis, and structure–activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists". MedChemComm 1: 54. doi:10.1039/c0md00022a.  edit
2. ^ Zuurman L, Passier PC, de Kam M, Kleijn HJ, Cohen AF, van Gerven JM (August 2009). "Pharmacodynamic and pharmacokinetic effects of the intravenously administered CB1 receptor agonist Org 28611 in healthy male volunteers". Journal of Psychopharmacology (Oxford, England) 23 (6): 633–44. doi:10.1177/0269881108091551. PMID 18635703. 
3. ^ A Comparison of Analgesic Efficacy Between a Single Dose of ORG 28611, Morphine, and Placebo After Dental Impaction Surgery

This cannabinoid related article is a stub. You can help Wikipedia by expanding it.v · Categories: Cannabinoids Cannabinoid stubs Wikimedia Foundation. 2010. Игры ⚽ Нужна курсовая? Org 28312 Orga, Cyprus Look at other dictionaries: Org 28312 — Systematic (IUPAC) name [1 (cyclohexylmethyl) 7 methoxyindol 3 yl] ((3S,5R) 3,4,5 trimethylpiperazin 1 yl)methanone Clinical data Pregnancy cat …   Wikipedia Org 27569 — Systematic (IUPAC) name 5 chloro 3 ethyl 1H indole 2 carboxylic acid [2 (4 piperidin 1 yl phenyl)ethyl]amide Clinical data Pregnancy cat …   Wikipedia JWH-018 — Systematic (IUPAC) name Naphthalen 1 yl (1 pentylindol 3 yl)methanone …   Wikipedia N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide — Systematic (IUPAC) name 7 methoxy 1 (2 morpholinoethyl) N ((1S,2S,4R) 1,3,3 trimethylbicyclo[2.2.1]heptan 2 yl) 1H indole 3 carboxamide C …   Wikipedia Cannabis (drug) — Marijuana redirects here. For other uses, see Marijuana (disambiguation). For the plant genus, see Cannabis. Cannabis …   Wikipedia Effects of cannabis — Short term effects of cannabis Classification and external resources ICD 10 F12.0 The effects of cannabis are caused by cannabinoids, most notably tetrahydrocannabinol (THC). Cannabis has both psychological and physiological effects on the human… …   Wikipedia Tetrahydrocannabinol — THC redirects here. For other uses, see THC (disambiguation). Tetrahydrocannabinol (THC) …   Wikipedia Paracetamol — Acetaminophen Systematic (IUPAC) name …   Wikipedia Oleamide — Oleamide[1] IUPAC name (Z) Octa 9 decenami …   Wikipedia Cannabinoid receptor antagonist — The discovery of the endogenous cannabinoid system led to the development of CB1 receptor antagonists. The first cannabinoid receptor antagonist, rimonabant, was described in 1994. Rimonabant blocks the CB1 receptor selectively and it has been… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”