O-806

O-806

Systematic (IUPAC) name
(6aR)-3-(6-bromohex-2-ynyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
ATC code	?
PubChem	CID 10549140
ChemSpider	26001356 Y
Chemical data
Formula	C22H27BrO2
Mol. mass	403.352 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C22H27BrO2/c1-15-9-10-18-17(12-15)21-19(24)13-16(8-6-4-5-7-11-23)14-20(21)25-22(18,2)3/h9,13-14,17-18,24H,5,7-8,10-12H2,1-3H3/t17-,18-/m1/s1 Y Key:QHFROVGTWNPDOW-QZTJIDSGSA-N Y
Y(what is this?)  (verify)

O-806 is a drug which is a cannabinoid derivative that is used in scientific research. It is described as a mixed agonist/antagonist at the cannabinoid receptor CB₁, meaning that it acts as an antagonist when co-administered alongside a more potent CB₁ agonist, but exhibits weak partial agonist effects when administered by itself.^[1][2]

References

1. ^ Griffin, G.; Wray, E.; Rorrer, W.; Crocker, P.; Ryan, W.; Saha, B.; Razdan, R.; Martin, B. et al. (1999). "An investigation into the structural determinants of cannabinoid receptor ligand efficacy". British journal of pharmacology 126 (7): 1575–1584. doi:10.1038/sj.bjp.0702469. PMC 1565939. PMID 10323589. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1565939.  edit
2. ^ Griffin, G.; Wray, E.; Martin, B.; Abood, M. (1999). "Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum". British journal of pharmacology 128 (3): 684–688. doi:10.1038/sj.bjp.0702806. PMC 1571656. PMID 10516649. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1571656.  edit

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