Difloxacin

Difloxacin

Systematic (IUPAC) name
6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)- 4-oxoquinoline-3-carboxylic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Routes	Oral
Identifiers
CAS number	98106-17-3 Y 91296-86-5 (HCl)
ATCvet code	QJ01MA94
PubChem	CID 56206
UNII	5Z7OO9FNFD N
KEGG	D07828 Y
ChEMBL	CHEMBL6259 N
Chemical data
Formula	C21H19F2N3O3
Mol. mass	399.39 g/mol
N(what is this?)  (verify)

Difloxacin (INN) is a fluoroquinolone antibiotic used in veterinary medicine.^[1] Although a broad-spectrum antimicrobial, its efficacy is not as good as enrofloxacin or pradofloxacin^[2].

See also

• Quinolone
• Adverse effects of fluoroquinolones

References

1. ^ Chidiac, C.; Mouton, Y. (1991). "Quinolones in the treatment of lower respiratory tract infections caused by intracellular pathogens.". Infection 19 Suppl 7: S365-71. PMID 1804785. 
2. ^ Silley P et al (2007) Comparative activity of pradofloxacin against anaerobic bacteria isolated from dogs and cats. J Antimicrob Chemother 60(5):999-1003

Other/ungrouped

sulfanilamide (Sulfacetamide, Sulfametrole)

Combinations

Trimethoprim/sulfamethoxazole^#

Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication)

1st g.	Cinoxacin‡ • Flumequine • Nalidixic acid • Oxolinic acid • Pipemidic acid • Piromidic acid • Rosoxacin
Fluoro- quinolones	2nd g. Ciprofloxacin#  • Enoxacin‡ • Fleroxacin‡ • Lomefloxacin • Nadifloxacin • Ofloxacin • Norfloxacin • Pefloxacin • Rufloxacin 3rd g. Balofloxacin • Grepafloxacin‡ • Levofloxacin • Pazufloxacin • Sparfloxacin‡ • Temafloxacin‡ • Tosufloxacin 4th g. Besifloxacin • Clinafloxacin† • Garenoxacin • Gemifloxacin • Moxifloxacin • Gatifloxacin‡ • Sitafloxacin • Trovafloxacin‡/Alatrofloxacin‡ • Prulifloxacin Vet. Danofloxacin • Difloxacin • Enrofloxacin • Ibafloxacin • Marbofloxacin • Orbifloxacin • Pradofloxacin • Sarafloxacin Related (DG) Aminocoumarins: Novobiocin

Anaerobic DNA
inhibitors

Nitro- imidazole derivatives	Metronidazole#  • Tinidazole • Ornidazole
Nitrofuran derivatives	Nitrofurantoin#  • Furazolidone‡  • Nifurtoinol

RNA synthesis

Rifamycins/ RNA polymerase

Rifampicin • Rifabutin • Rifapentine • Rifaximin

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: BAC bact (clas) gr+f/gr+a(t)/gr-p(c)/gr-o drug(J1p, w, n, m, vacc)