F2RL3

F2RL3
Coagulation factor II (thrombin) receptor-like 3
Identifiers
Symbols F2RL3; PAR4
External IDs OMIM602779 MGI1298207 HomoloGene36148 IUPHAR: PAR4 GeneCards: F2RL3 Gene
RNA expression pattern
PBB GE F2RL3 207221 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9002 14065
Ensembl ENSG00000127533 ENSMUSG00000050147
UniProt Q96RI0 Q0VDX1
RefSeq (mRNA) NM_003950 NM_007975.3
RefSeq (protein) NP_003941 NP_032001.2
Location (UCSC) Chr 19:
17 – 17 Mb
Chr 8:
75.29 – 75.29 Mb
PubMed search [1] [2]

Protease-activated receptor 4 (PAR4), previously known as Coagulation factor II (thrombin) receptor-like 3, is a protein encoded by the F2RL3 gene in humans.[1]

Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.[1]

Contents

See also

References

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Metabolites and
signaling molecules
Peptide
Miscellaneous
Class B: Secretin like Class C: Metabotropic
glutamate / pheromone Class F:
Frizzled / Smoothened
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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Look at other dictionaries:

  • Protease-activated receptor — protein Name = coagulation factor II (thrombin) receptor caption = width = HGNCid = 3537 Symbol = F2R AltSymbols = PAR1 EntrezGene = 2149 OMIM = 187930 RefSeq = NM 001992 UniProt = P25116 PDB = ECnumber = Chromosome = 5 Arm = q Band = 13… …   Wikipedia

  • F2RL2 — Coagulation factor II (thrombin) receptor like 2 Identifiers Symbols F2RL2; PAR3 External IDs …   Wikipedia

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