P2RY1

P2RY1
Purinergic receptor P2Y, G-protein coupled, 1
Identifiers
Symbols P2RY1; P2Y1
External IDs OMIM601167 MGI105049 HomoloGene1926 GeneCards: P2RY1 Gene
RNA expression pattern
PBB GE P2RY1 207455 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5028 18441
Ensembl ENSG00000169860 ENSMUSG00000027765
UniProt P47900 Q544J5
RefSeq (mRNA) NM_002563.2 NM_008772.4
RefSeq (protein) NP_002554.1 NP_032798.1
Location (UCSC) Chr 3:
152.55 – 152.56 Mb
Chr 3:
60.81 – 60.81 Mb
PubMed search [1] [2]

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.[1]

The product of this gene, P2Y1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.[2]

Contents

See also

References

  1. ^ Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (Mar 1996). "Cloning and chromosomal localization of the human P2Y1 purinoceptor". Biochem Biophys Res Commun 218 (3): 783–788. doi:10.1006/bbrc.1996.0139. PMID 8579591. 
  2. ^ "Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5028. 

External links

Further reading

Metabolites and
signaling molecules
Peptide
Miscellaneous
Class B: Secretin like Class C: Metabotropic
glutamate / pheromone Class F:
Frizzled / Smoothened B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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Look at other dictionaries:

  • P2Y receptor — P2Y receptors are a family of purinergic receptors, G protein coupled receptors stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP glucose. To date, 12 P2Y receptors have been cloned in humans: P2Y1, P2Y2, P2Y4, P2Y5, P2Y6, P2Y8, P2Y9… …   Wikipedia

  • Rhodopsin-like receptors — Pfam box Symbol = 7tm 1 Name = Rhodopsin like receptors width = caption = Pfam= PF00001 InterPro= IPR000276 SMART= PROSITE = PDOC00211 SCOP = 1f88 TCDB = OPM family= 6 OPM protein= 1gzm PDB=Rhodopsin like receptors are the largest group of G… …   Wikipedia

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