DNA damage-inducible transcript 3

DNA damage-inducible transcript 3
DNA-damage-inducible transcript 3
Symbols DDIT3; CEBPZ; CHOP; CHOP-10; CHOP10; GADD153; MGC4154
External IDs OMIM126337 MGI109247 HomoloGene3012 GeneCards: DDIT3 Gene
RNA expression pattern
PBB GE DDIT3 209383 at tn.png
More reference expression data
Species Human Mouse
Entrez 1649 13198
Ensembl ENSG00000175197 ENSMUSG00000025408
UniProt P35638 Q3V405
RefSeq (mRNA) NM_001195053.1 NM_007837.3
RefSeq (protein) NP_001181982.1 NP_031863.3
Location (UCSC) Chr 12:
57.91 – 57.91 Mb
Chr 10:
126.73 – 126.73 Mb
PubMed search [1] [2]

DNA damage-inducible transcript 3 is a protein that in humans is encoded by the DDIT3 gene.[1][2]



DNA damage-inducible transcript 3 has been shown to interact with Casein kinase 2, alpha 1,[3] JunD,[4] RPS3A,[5] ATF3,[6] CEBPB,[7][8] C-jun[4] and C-Fos.[4]


  1. ^ Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, Alamo I Jr, Barrett SF, Hickson ID, Fornace AJ Jr (Mar 1991). "Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C". Mol Cell Biol 11 (2): 1009–16. PMC 359769. PMID 1990262. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=359769. 
  2. ^ "Entrez Gene: DDIT3 DNA-damage-inducible transcript 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1649. 
  3. ^ Ubeda, Mariano; Habener Joel F (Oct. 2003). "CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation". J. Biol. Chem. (United States) 278 (42): 40514–20. doi:10.1074/jbc.M306404200. ISSN 0021-9258. PMID 12876286. 
  4. ^ a b c Ubeda, M; Vallejo M, Habener J F (Nov. 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7589–99. ISSN 0270-7306. PMC 84780. PMID 10523647. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84780. 
  5. ^ Cui, K; Coutts M, Stahl J, Sytkowski A J (Mar. 2000). "Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis". J. Biol. Chem. (UNITED STATES) 275 (11): 7591–6. doi:10.1074/jbc.275.11.7591. ISSN 0021-9258. PMID 10713066. 
  6. ^ Chen, B P; Wolfgang C D, Hai T (Mar. 1996). "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10". Mol. Cell. Biol. (UNITED STATES) 16 (3): 1157–68. ISSN 0270-7306. PMC 231098. PMID 8622660. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231098. 
  7. ^ Hattori, Takayuki; Ohoka Nobumichi, Hayashi Hidetoshi, Onozaki Kikuo (Apr. 2003). "C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform". FEBS Lett. (Netherlands) 541 (1–3): 33–9. doi:10.1016/S0014-5793(03)00283-7. ISSN 0014-5793. PMID 12706815. 
  8. ^ Fawcett, T W; Eastman H B, Martindale J L, Holbrook N J (Jun. 1996). "Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress". J. Biol. Chem. (UNITED STATES) 271 (24): 14285–9. doi:10.1074/jbc.271.24.14285. ISSN 0021-9258. PMID 8662954. 

Further reading

External links

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