NFIC (gene)

Nuclear factor I/C (CCAAT-binding transcription factor)
Identifiers
Symbols	NFIC; CTF; CTF5; MGC20153; NF-I; NFI
External IDs	OMIM: 600729 MGI: 109591 HomoloGene: 4088 GeneCards: NFIC Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity Cellular component • intracellular • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • DNA replication • transcription, DNA-dependent • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4782	18029
Ensembl	ENSG00000141905	ENSMUSG00000055053
UniProt	P08651	Q3UHA6
RefSeq (mRNA)	NM_005597.2	NM_008688
RefSeq (protein)	NP_005588.2	NP_032714
Location (UCSC)	Chr 19: 3.36 – 3.46 Mb	Chr 10: 80.86 – 80.89 Mb
PubMed search	[1]	[2]

Nuclear factor 1 C-type is a protein that in humans is encoded by the NFIC gene.^[1][2][3]

References

1. ^ Santoro C, Mermod N, Andrews PC, Tjian R (Aug 1988). "A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs". Nature 334 (6179): 218–24. doi:10.1038/334218a0. PMID 3398920. 
2. ^ Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749. 
3. ^ "Entrez Gene: NFIC nuclear factor I/C (CCAAT-binding transcription factor)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4782. 

Further reading

• Blau J, Xiao H, McCracken S, et al. (1996). "Three functional classes of transcriptional activation domain.". Mol. Cell. Biol. 16 (5): 2044–55. PMC 231191. PMID 8628270. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231191. 
• Wenzelides S, Altmann H, Wendler W, Winnacker EL (1996). "CTF5--a new transcriptional activator of the NFI/CTF family.". Nucleic Acids Res. 24 (12): 2416–21. doi:10.1093/nar/24.12.2416. PMC 145930. PMID 8710515. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=145930. 
• Liu Y, Bernard HU, Apt D (1997). "NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing.". J. Biol. Chem. 272 (16): 10739–45. doi:10.1074/jbc.272.16.10739. PMID 9099724. 
• Nogues G, Kadener S, Cramer P, et al. (2003). "Transcriptional activators differ in their abilities to control alternative splicing.". J. Biol. Chem. 277 (45): 43110–4. doi:10.1074/jbc.M208418200. PMID 12221105. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Norquay LD, Yang X, Sheppard P, et al. (2003). "RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin.". Mol. Endocrinol. 17 (6): 1027–38. doi:10.1210/me.2003-0025. PMID 12624117. 
• Wickenheisser JK, Nelson-DeGrave VL, Quinn PG, McAllister JM (2004). "Increased cytochrome P450 17alpha-hydroxylase promoter function in theca cells isolated from patients with polycystic ovary syndrome involves nuclear factor-1.". Mol. Endocrinol. 18 (3): 588–605. doi:10.1210/me.2003-0090. PMID 14684846. 
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824. 
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Zhao LH, Ba XQ, Wang XG, et al. (2005). "BAF complex is closely related to and interacts with NF1/CTF and RNA polymerase II in gene transcriptional activation.". Acta Biochim. Biophys. Sin. (Shanghai) 37 (7): 440–6. doi:10.1111/j.1745-7270.2005.00061.x. PMID 15999204. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Nilsson J, Bjursell G, Kannius-Janson M (2006). "Nuclear Jak2 and transcription factor NF1-C2: a novel mechanism of prolactin signaling in mammary epithelial cells.". Mol. Cell. Biol. 26 (15): 5663–74. doi:10.1128/MCB.02095-05. PMC 1592781. PMID 16847321. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1592781. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• Hebbar PB, Archer TK (2007). "Chromatin-dependent cooperativity between site-specific transcription factors in vivo.". J. Biol. Chem. 282 (11): 8284–91. doi:10.1074/jbc.M610554200. PMC 2528297. PMID 17186943. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2528297. 

External links

• MeSH NFIC+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.