Pre-B-cell leukemia homeobox 2

Cartoon diagram of a HOXB1PBX1 heterodimer (violet) binding a DNA fragment (blue). Rendering based on PDB 1b72.
Symbols PBX2; G17; HOX12; PBX2MHC
External IDs OMIM176311 MGI1341793 HomoloGene48115 GeneCards: PBX2 Gene
RNA expression pattern
PBB GE PBX2 202876 s at tn.png
PBB GE PBX2 202875 s at tn.png
PBB GE PBX2 211096 at tn.png
More reference expression data
Species Human Mouse
Entrez 5089 18515
Ensembl ENSG00000204304 ENSMUSG00000034673
UniProt P40425 Q3TMM2
RefSeq (mRNA) NM_002586 NM_017463.2
RefSeq (protein) NP_002577 NP_059491.1
Location (UCSC) Chr 6:
32.26 – 32.27 Mb
Chr 17:
34.73 – 34.73 Mb
PubMed search [1] [2]

Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.[1][2]

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.[2]



PBX2 has been shown to interact with HOXA9.[3]


  1. ^ Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T (Feb 1995). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics 23 (2): 408–19. doi:10.1006/geno.1994.1517. PMID 7835890. 
  2. ^ a b "Entrez Gene: PBX2 pre-B-cell leukemia homeobox 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5089. 
  3. ^ Shen, W F; Rozenfeld S, Kwong A, Köm ves L G, Lawrence H J, Largman C (Apr. 1999). "HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells". Mol. Cell. Biol. (UNITED STATES) 19 (4): 3051–61. ISSN 0270-7306. PMC 84099. PMID 10082572. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84099. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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